INOREVIA
Technology
Inorevia's technology stems from over 10 years of research in the field of Microfluidics at the Institut Curie in Paris, one of the lab pioneer in this field.
What is microfluidics?
Microfluidics is to plumbing what microelectronics is to electricity: a revolution.
The cornerstone of this revolution is miniaturization at the micrometer scale, bringing new properties to the liquids handled: capillary rise of tree sap, micro-encapsulation of active ingredient, etc.
Miniaturization is also beneficial to technical components of studies and analysis of biological samples (e.g. lab-on-chip, medical diagnosis from a drop of blood), as well as medical devices (micropumps for injecting insulin into liver).
This scientific, technical and medical revolution is not new: 2 billion years ago the porous cell membrane, 400 million years ago the first tree (archaeopteris), in 1976 inkjet printer (IBM 4640), in 2000 the first microfluidic chip in PDMS, in 2015 a rapid diagnosis of the Ebola virus on a strip of paper, and today the Magelia.
Do more, faster, less expensive, with less sample, this is the major contribution of microfluidics on which the scientific and technical expertise of Inorevia is based.
The cornerstone of this revolution is miniaturization at the micrometer scale, bringing new properties to the liquids handled: capillary rise of tree sap, micro-encapsulation of active ingredient, etc.
Miniaturization is also beneficial to technical components of studies and analysis of biological samples (e.g. lab-on-chip, medical diagnosis from a drop of blood), as well as medical devices (micropumps for injecting insulin into liver).
This scientific, technical and medical revolution is not new: 2 billion years ago the porous cell membrane, 400 million years ago the first tree (archaeopteris), in 1976 inkjet printer (IBM 4640), in 2000 the first microfluidic chip in PDMS, in 2015 a rapid diagnosis of the Ebola virus on a strip of paper, and today the Magelia.
Do more, faster, less expensive, with less sample, this is the major contribution of microfluidics on which the scientific and technical expertise of Inorevia is based.
How does Magelia works?
Magelia uses a patented combination of both Microfluidics and the manipulation of magnetic micro-particles (magnetic beads) to perform complex protocols in a fully automated way while downscaling reactional volumes.
The “microfluidic magnetic tweezers” technology consists of a very precisely controlled magnetic field that works in the close vicinity of a microfluidic capillary. By switching on and off the magnetic field, magnetic beads (typically in the micrometer diameter range) are transported from one moving droplet to another. Each droplet represents one step of the library preparation protocol. In this way it is possible to automatically achieve a complex sequence of biological reactions, using droplets as microreactors and beads as microcarriers of samples (DNA, RNA, ...). A series of modules for heating, cooling, mixing, extracting, and merging is used during sample preparation to treat samples. Magnetic beads contained in a droplet are displaced above each of these modules in a very controlled and reproducible manner through high-precision liquid displacement and proprietary optical droplet detection and positioning.
